home/categories/bioinformatics/gptomics-bioskills-comparative-genomics-ancestral-reconstruction-skill-md
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bio-comparative-genomics-ancestral-reconstruction
Reconstruct ancestral sequences at phylogenetic nodes using PAML and IQ-TREE marginal likelihood methods. Infer ancient protein sequences and trace evolutionary trajectories through sequence history. Use when inferring ancestral states for protein resurrection or tracing evolutionary history.
maintainer
GPTomics
Updated 4/6/2026
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quick start
Installation and usage
Reconstruct ancestral sequences at phylogenetic nodes using PAML and IQ-TREE marginal likelihood methods. Infer ancient protein sequences and trace evolutionary trajectories through sequence history. Use when inferring ancestral states for protein resurrection or tracing evolutionary history.
Installation
$ install --globalskills.sh
Usage
Once installed, you can use this skill by running the following command in your terminal:
skills use bio-comparative-genomics-ancestral-reconstruction